Chitosan

Common name

N/A

ID

HD0120

Scientific name of the plant

N/A

Anatomical part for use

N/A

Human use

Weight Control

Summary

Chitosan is a linear polysaccharide composed of randomly distributed β-(1→4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit). It is made by treating the chitin shells of shrimp and other crustaceans with an alkaline substance, such as sodium hydroxide. Chitosan has a number of commercial and possible biomedical uses. It can be used in agriculture as a seed treatment and biopesticide, helping plants to fight off fungal infections. In winemaking, it can be used as a fining agent, also helping to prevent spoilage. In industry, it can be used in a self-healing polyurethane paint coating. In medicine, it is useful in bandages to reduce bleeding and as an antibacterial agent; it can also be used to help deliver drugs through the skin.

Evidence Level

Level 0 (No convinced report of liver injury caused by herbal and dietary supplement)

Hepatotoxicity Description

N/A

Medical use

Chitosan is used within some wound dressings to decrease bleeding. It received approval for medical use in the United States in 2003. It also may decrease the growth of bacteria and fungus, and may be useful as a burn dressing.Chitosan hemostatic agents are salts made from mixing chitosan with an organic acid (such as succinic or lactic acid). The hemostatic agent works by an interaction between the cell membrane of erythrocytes (negative charge) and the protonated chitosan (positive charge) leading to involvement of platelets and rapid thrombus formation. (Source: Wiki)

Research

Chitosan and derivatives have been explored in the development of nanomaterials, bioadhesives, wound dressing materials, improved drug delivery systems, enteric coatings, and in medical devices. Chitosan nanofiber membranes have a high degree of biocompatibility and may support new bone formation. Chitosan-derived metallic nanomaterials are under study for wound healing. Chitosan is under research as an adjuvant for a potential intranasal vaccine delivery method. (Source: Wiki)

Relevant Public Information

Wiki
NIH ODS
Nature Medicines